Persistence of phencyclidine in fetal brain
نویسندگان
چکیده
منابع مشابه
Gestational exposure to phencyclidine (PCP) in rats decreases PCP binding sites in term fetal brain.
Pregnant Sprague-Dawley rats were treated with 5 mg/kg body weight of phencyclidine (PCP) injected at 1 ml/kg subcutaneously on three consecutive days at four different stages of gestation. Within 10-30 min after treatment, dams showed some lack of motor coordination and became lethargic. On gestational day 21, all rats were killed by decapitation and brains were dissected and stored from mothe...
متن کاملAnti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats.
These studies examined the hypothesis that a single large dose of monoclonal anti-phencyclidine (PCP) antibody could provide long-term reductions in brain PCP concentrations despite continuous PCP administration. PCP (18 mg/kg/day, s.c.) was infused to steady-state (24 h) and then a mole-equivalent dose of a short-acting anti-PCP antigen-binding fragment (Fab) or a long-acting anti-PCP IgG was ...
متن کاملPersistence of Fetal Ductus Function
Within recent years there has been increasing interest in the presence of reversed flow through the ductus arteriosus. Most reported cases have been in older children and young adults. There is a group of cases in which the ductus serves as a site of a veno-arterial shunt in infancy, and thus continues to perform its fetal function. The conditions under which veno-arterial shunting persists aft...
متن کاملPersistence of Fetal Ductus Function
Within recent years there has been increasing interest in the presence of reversed flow through the ductus arteriosus. Most reported cases have been in older children and young adults. There is a group of cases in which the ductus serves as a site of a veno-arterial shunt in infancy, and thus continues to perform its fetal function. The conditions under which veno-arterial shunting persists aft...
متن کاملPersistence of Fetal Ductus Function
Within recent years there has been increasing interest in the presence of reversed flow through the ductus arteriosus. Most reported cases have been in older children and young adults. There is a group of cases in which the ductus serves as a site of a veno-arterial shunt in infancy, and thus continues to perform its fetal function. The conditions under which veno-arterial shunting persists aft...
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ژورنال
عنوان ژورنال: Brain Research
سال: 1987
ISSN: 0006-8993
DOI: 10.1016/0006-8993(87)90287-3